It’s Here! Your 20 Frequently Asked Questions About 40+ and 55+ Answered
You asked and we’re answering your most frequently asked questions (FAQs) about MenoMe® 40+ and 55+.
Because when you’re taking – or thinking of taking – something to support you during menopause you want to do your homework.
Indeed, when it comes to your health you want to dot your i’s and cross your t’s. Right?
So, we’ve got you covered.
The 20 most frequently asked questions about 40+ and 55+
1. What does 40+ contain?
40+ comprises pure EstroG-100™. As such, it’s a patented formulation that’s been the subject of published scientific studies on menopause1. And these studies have shown EstroG-100™ support women in pre-, peri- and post-menopause.
EstroG-100™ combines the roots of three herbs: Cynanchum wilfordii (Milkweed), Phlomis umbrosa (Jerusalem sage) and Angelica gigas nakai (Angelica).
To clarify, Cynanchum are climbing vines, Phlomis are sage-like herbs and Angelica is used as a food, herbal remedy and flavour. Further, these herbs have been used for hundreds of years as culinary herbs in Korea and have a long history of use in folk medicine.
Phlomis umbrosa is wild-harvested, while Cynanchum wilfordii and Angelica gigas nakai are cultivated.
2. What does 55+ contain?
55+ also contains EstroG-100™. Additionally, it has the added support of Enzogenol® pine bark extract, marine magnesium and Vitamin D3.
Enzogenol®
Enzogenol® is derived from the bark of New Zealand radiata pine trees using a water-only extraction process. What’s more, it contains more than 80% proanthocyanidins making it a potent antioxidant. Indeed, antioxidants play an important role in reducing oxidative stress and damage associated with the ageing process. Furthermore, in scientific research, Enzogenol® has been shown to support cardiovascular and eye health as well as healthy brain function in relation to mental clarity and focus.
Marine Magnesium
The marine magnesium we use is derived from red algae seaweed from Icelandic seawater. Furthermore, it also contains calcium and 72 trace minerals. However, 60-80% of adults don’t consume the recommended daily intake of magnesium in their diets. In addition, absorption of magnesium from the small intestine decreases and excretion from the kidneys increases as we age. For these reasons, magnesium supplementation is increasingly used. The quality of magnesium depends not only on its source but also its bioavailability – the ability to be absorbed and utilised by the body. The magnesium we use is highly absorbable.
Vitamin D3
Vitamin D3 is sunshine in a capsule. In addition to its well-known role in supporting bone health, it supports healthy immune function, mood, sleep, joints and weight. For women, vitamin D levels generally start to decline during the midlife transition.
3. Does EstroG-100™ contain estrogen?
No, EstroG-100™ does not contain any estrogenic properties. In addition, it doesn’t contain coumestans, isoflavones, genistein, daidzein, biochanin A or formononetin. And unlike other herbal ingredients for menopause, EstroG-100™ does not bind to estrogen receptors alpha and beta and it does not proliferate MCF-7 cells. Therefore, it is safe to take if you have had, or are at risk of hormone-sensitive breast cancer. What’s more, EstroG-100™ doesn’t affect FSH/E2, uterus weight, BMI and body weight.
4. How does EstroG-100™work?
The available scientific evidence suggests the mechanism of action for EstroG-100™ supporting menopausal balance and bone metabolism is due to its support for a selective estrogen receptor modulator (SERM2). Certain plant compounds in EstroG-100™ support balanced estrogen metabolism. This works in harmony with your own body’s metabolic and biochemical pathways. SERMs are also believed to have neuroprotective qualities3.
5. Should I choose 40+ or 55+?
That’s a great question and we’re glad you asked.
We designed 40+ for women in perimenopause and 55+ for women in post-menopause.
Both 40+ and 55+ contain the same amount of EstroG-100™ (see above). So they provide the same level of hormone-balancing properties to help alleviate many of the symptoms of menopause.
The difference between the two is that 55+ also contains Enzogenol® pine bark extract, marine magnesium and vitamin D3 (see above). The added ingredients provide extra support for bone, brain and heart health as well as moods and sleep.
In other words, 55+ is an all-in-one supplement that supports you through many of the well-known symptoms of menopause (beginning during perimenopause and continuing into post-menopause). However, it also provides antioxidant support for degenerative diseases that become a higher risk to women in their post-menopause years.
Of course, you may choose 40+ in post-menopause or 55+ in perimenopause. The choice is yours and will depend on your budget and other supplements you may be taking.
Or, you may want extra support before entering post-menopause. Either way, we have you covered at MenoMe®.
6. How do I take 40+ and 55+?
Take two capsules together daily either morning or night.
7. Can I expect better or faster results with a higher dose?
The published scientific studies all used the same dose of EstroG-100™. However, we have anecdotal evidence from many years of usage that showed some women had benefitted by taking EstroG-100™ more frequently.
8. How long do 40+ and 55+ take to work?
This varies with individuals (thankfully we are all different!) – but based on our scientific research, you can expect to notice support within six weeks. However, when we look at experience, it can take from one to four weeks. The fastest case we know of was within two days! Optimum results are usually reached within 12 weeks.
If you are one of the few women who don’t feel improvement we offer a 60-Day money-back guarantee.
Read: How To Take 40+ and 55+ For Best Results
9. What can I expect when taking 40+ or 55+?
Every woman is different. The effects can be dramatic for some and more subtle for others, with reports of an overall sense of calmness occurring. We recommend that you keep taking 40+ throughout your perimenopause even if the effects fluctuate at times. This will enhance a more balanced hormonal experience during your menopausal journey compared to not taking 40+.
10. Can you take 40+ and 55+ with other supplements?
Yes. There are no known interactions with 40+.
11. Can you take 40+ and 55+ with other medicines?
If you are taking anti-thrombotic or anticoagulant medications consult with your doctor before taking 40+.
12. How long should I take 40+ or 55+ for?
It is advisable to keep taking 40+ throughout your perimenopause. Once your periods have stopped for 12 continuous months you are officially in post-menopause at which stage we recommend you switch to 55+. And remain for taking it as we become vulnerable to osteoporosis, heart disease and dementia as we age.
13. Why do I experience hormonal fluctuations, even when I am taking 40+ or 55+?
Everything in nature has rhythms and cycles – peaks and troughs. There is no stronger example of the ebbs and flows in our body chemistry than a woman’s monthly cycle. Some women will experience much higher peaks and lower troughs than others, and will therefore have more severe experiences than others.
40+ supports balance for these highs and lows, but will not eliminate them to a flat line. This is because of the way 40+ and 55+ work; to help balance your own natural hormone levels. 40+ does not contain estrogens but works to support your own naturally produced hormones. As such it will smooth but not completely flatten the cyclic rhythm. This is the most natural way to manage your menopause and results in outstanding quality-of-life scores when measured in our scientific research.
14. Are there any possible adverse reactions from 40+ or 55+?
There were no noted adverse reactions during the scientific studies. However, there may be a temporary itching or rash on the skin for people who are sensitive to taking new materials. The EstroG-100™ helps purify the bloodstream, and urticarial (skin rash/hives) may very rarely occur due to the detoxification process. Should this happen reduce the dose to one capsule per day, or every second day. If symptoms persist stop taking for a week and then resume.
15. Is 40+ suitable for women with endometriosis?
40+ does not have estrogenic activity and has not been specifically tested for safety or efficacy for endometriosis. However, in the menopause scientific studies, endometriosis was not a requirement for the exclusion of participants in the trials. Only patients with cervical cancer, endometrial cancer, breast cancer, and sex hormone-related cancers were excluded.
16. Are 40+ or 55+ suitable for women who have an underactive thyroid?
EstroG-100™ has not been shown to affect thyroid function, but no studies have been conducted to prove safety for women with an underactive thyroid. However, in scientific studies for menopause, subjects with thyroid disease participated where their medical practitioner judged them suitable.
17. Who should not take 40+ and 55+?
Pregnant or lactating women and those taking anti-thrombotic or anti-coagulant* products should consult your health practitioner before taking EstroG-100™.
*There have been no reported interactions or side effects when taking antithrombotics or anti-coagulants while on MenoMe® 40+, or the active ingredient EstroG-100™. However, one of the herbs, Angelica, is known to have anti-coagulant and anti-thrombotic effects when taken in higher doses. Therefore in Korea, the Food and Drug Administration requires that there should be an advisory statement on healthy functional foods containing Angelica. This advisory is not required in other countries, including New Zealand (where it is regulated as a dietary supplement) and Canada, (where it is registered as a Natural Health Product).
18. Can men take 40+ or 55+?
There is no harm in men taking the EstroG-100™ in 40+ and 55+ but there is no evidence it will assist them in any way.
19. How should I store 40+ and 55+?
Keep in a cool dry place, away from direct sunlight and moisture.
20. What is the shelf life for 40+ and 55+?
40+ and 55+ are shelf-stable for three years (36 months).
We hope this helped with some of your queries. Of course, if you have any other burning questions please get in touch with us. We’re here to help.
Natural Menopause Support
Our natural herbal formulation is scientifically validated to support women in all stages of menopause
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References
- Chang A, Kwak BY, Yi K, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012 Apr;26(4):510-6. doi: 10.1002/ptr.3597. Epub 2011 Sep 2. PMID: 21887807.
- Lewis JS, Jordan VC. Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance. Mutat Res. 2005 Dec 11;591(1-2):247-63. doi: 10.1016/j.mrfmmm.2005.02.028. Epub 2005 Aug 3. PMID: 16083919.
- Maria Angeles, Arevalo, Maria Santo-Galimdo. Natalia Lagunas, Inigo Azcoitia, Luis M Garcia-Segura. Selective estrogen receptor modulators as brain therapeutic agents. Journal of Molecular Endocrinology. 01 Feb 2011. doi JME-10-0122
